Molecular Characterization of Indolent Prostate Cancer
Abstract
Indolent prostate cancers that pose very low risk to aged men occur frequently and may be detected at biopsy, leading to the contemporary problem of prostate cancer over-diagnosis and over-treatment. The objective of the project is to define and characterize indolent prostate cancer using genomic approaches in the clinically relevant context of a cohort meeting the entry criteria for active surveillance. During this funding period, we collaborated with urologists and pathologists involved in the active surveillance program, and focused on evaluation of technical feasibility, acquisition of specimen resources, and optimization of the workflow. Our preliminary work established that high quality nucleic acid molecules can be extracted from laser captured small tumor lesions present in men diagnosed with very low risk prostate cancer, setting the stage for large-scale genomic studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA590674
Entities
People
- Jun Luo
Organizations
- Johns Hopkins University