Regulation of Mammary Tumor Formation and Lipid Biosynthesis by Spot 14
Abstract
This study was designed to determine the role of the fatty acid synthesis regulatory protein, Spot14 (S14) in mammary tumorigenesis. We have generated mouse models to identify effects of S14 overexpression and S14 loss on mammary tumor formation, growth, metabolism, and metastasis. To date, we have determined that S14 overexpression shortens mammary tumor latency, increases tumor fatty acid synthesis, but inhibits tumor metastasis. We found that tumors overexpressing S14 were well differentiated compared to control tumors, which likely explains their decreased metastatic ability. Conversely, loss of S14 did not affect tumor latency, but resulted in slower tumor growth rates. Furthermore, many of the tumors that formed lacking S14 had a cystic morphology. These tumors also had reduced fatty acid synthesis. Overall, these studies show that S14 plays an important role in mammary tumor growth and metabolism.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA590676
Entities
People
- Elizabeth Wellberg
Organizations
- University of Colorado Boulder