Toxicity Evaluation of Engineered Nanomaterials: Risk Evaluation Tools (Phase 3 Studies)
Abstract
The overall objective was to develop a fundamental understanding of the interaction of engineered nanomaterials (NMs) with biological molecules that can be exploited to predict the toxicological effects and health risk in occupationally exposed humans. The specific objective was to develop the methodology to generate realistic NM airborne exposures, characterize NMs in situ, and estimate toxicity mechanisms and kinetics using predictive and computational models based on in vitro and in vivo data. The multiphase approach to this project involves consecutive and concurrent activities to develop a health risk evaluation system. We have successfully developed a realistic nanoaerosol exposure system that can be used to deposit NMs onto cells maintained at the air-liquid interface within a portable chamber for the investigation of NM toxicity. Future work will involve the routine investigation of NM toxicity using this system and correlation with traditional exposures.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2012
- Accession Number
- ADA590933
Entities
People
- Christin Grabinski
- Elizabeth Maurer
- Jerzy Leszczynski
- Mohan Sankaran
- Nicole Schaeublin
- Ravindra Pandey
- Saber Hussain
- William Trickler
Organizations
- Air Force Research Laboratory