Targeting Homology-Directed Recombinational Repair (HDR) of Chromosomal Breaks to Sensitize Prostate Cancer Cells to Poly (ADP-Ribose) Polymerase (PARP) Inhibition

Abstract

Previous reports suggest radiation induces BRCA1 nuclear export. We thus hypothesized that in prostate cancer cells, radiation will induce BRCA1 nuclear export and subsequently render tumor cells homologous recombination repair deficient. This, then, would render tumor cells susceptible to PARP inhibition, which target cells that are deficient in homologous recombination repair.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2013
Accession Number
ADA590934

Entities

People

  • Shih-hsin E. Yang

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Chemistry
  • Environmental Health
  • Health Services
  • Medical Personnel
  • Neoplasms
  • North America
  • Oncology
  • Prostate Cancer
  • Radiation Oncology
  • Radiotherapy
  • Students
  • Therapy

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Biology and Genetics