Sealing Penetrating Eye Injuries With Photoactivated Bonding
Abstract
To develop a light-activated technology with the potential to decrease vision loss and ocular complications in warfighters sustaining penetrating eye injuries. To establish, in ex vitro and in vivo animal models, the treatment parameters for sealing corneal and scleral penetrating wounds and to close lacerations in thin (eyelid-like) skin. To design and evaluate a prototype light delivery device. We established that bonding amniotic membrane over penetrating cornea and scleral wounds produced immediate, water-tight seals that withstood an intraocular pressure of 350 mm Hg. We closed lacerations in eyelid-like skin with the dye + light treatment, which showed less inflammation than after sutured closure. A prototype light delivery system was designed, constructed and tested to deliver retina-safe light levels while providing light levels sufficient for sealing amniotic membrane over corneal wounds. Studies demonstrated that thermal damage to the iris is not a concern during these repair treatments.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2013
- Accession Number
- ADA591047
Entities
People
- Irene E. Kochevar
Organizations
- Massachusetts General Hospital