Targeted Silver Nanoparticles for Dual-Energy Breast X-Ray Imaging
Abstract
We proposed to develop a silver (Ag) nanoparticle (NP) contrast agent optimized for dualenergy (DE) contrast-enhanced (CE) breast x-ray imaging. CE digital breast imaging provides an accurate method for decomposition of images into distinct breast tissue and contrast agent signals. At present, DE-CE breast imaging is performed with an iodinated contrast agent better suited for temporal subtraction CE imaging. We postulated that AgNP would be a superior contrast agent for DE-CE breast x-ray imaging. Ag filters can be used in the low-energy image acquisition to obtain a spectrum weighted just below the k-edge of Ag (25.5 keV). A low-energy spectrum optimized for Ag would also provide a superior anatomical image. We have demonstrated in proof-of-principle, the applicability of AgNP as contrast agents for use in DE-CE digital breast tomosynthesis and digital mammography. Three objectives have been met: 1) Synthesize and functionalize AgNP that are monodisperse in shape, size and distribution; 2) Perform vascular-enhancement, biodistribution and toxicity studies on mice; and 3) develop optimal x-ray imaging techniques.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2013
- Accession Number
- ADA591279
Entities
People
- Andrew D. Maidment
Organizations
- University of Pennsylvania