SNF5 Mutation Leads to Intractable Pain in Schwannomatosis Patients

Abstract

Ablation of snf5, in vivo, results in an increase in the number and type of sensory neurons that express the capsaicin receptor, TRPV1. Using a culture system, we have determined that soluble factor is released by snf5-/- Schwann cells that acts on sensory neurons to induce the expression of TRPV1. This factor is greater than 10K molecular weight and does not affect neuron survival. The increase in the immunoreactivity of TRPV1 is correlated with an increase in the expression of functional capsaicin-sensitive ion fluxes.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2013
Accession Number
ADA591283

Entities

People

  • Steven G. Matsumoto

Organizations

  • Oregon Health & Science University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Biomedical Research
  • Cell Count
  • Cells
  • Culture Techniques
  • Cultured Cells
  • Dermatologic Agents
  • Ganglia
  • Infection
  • Molecular Weight
  • Nervous System
  • Neurons
  • Pain
  • Peripheral Nervous System
  • Sciatic Nerve
  • Sensory Ganglia
  • Sensory Receptor Cells

Fields of Study

  • Biology

Readers

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