Thiourea-Catalyzed Aminolysis of N-acyl Homoserine Lactones

Abstract

Thiourea catalysts accelerate aminolysis of N-acyl homoserine lactones (AHLs), molecules integral to bacterial quorum sensing. The catalysts afford rate enhancement of up to 10 times the control in CD3CN. Mild catalysis in other polar aprotic solvents is still observed, while the activity is attenuated in polar protic solvents.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2013
Accession Number
ADA591316

Entities

People

  • Michael A. Bertucci
  • Michel R Gagné
  • Stephen J. Lee

Organizations

  • United States Army Research Laboratory

Tags

DTIC Thesaurus Topics

  • 1-Ring Heterocyclic Compounds
  • Amines
  • Catalysis
  • Catalysts
  • Chemical Synthesis
  • Chemistry
  • Communication Networks
  • Electronic Mail
  • Environment
  • Gram-Negative Bacteria
  • Homoserine
  • Information Operations
  • Microbiology
  • Military Research
  • Molecules
  • North Carolina
  • Small Molecules

Fields of Study

  • Chemistry

Readers

  • Microbial Pathology
  • Organic Chemistry