Mutation of Breast Cancer Cell Genomic DNA by APOBEC3B
Abstract
Over the course of my tenure on this training grant, I have discovered that an endogenous enzyme, APOBEC3B, is upregulated in the majority of breast cancers. This holds true for both primary cancer tissues as well as cell lines. I have mechanistically characterized the enzyme s activity, sub-cellular localization, preferred sequence substrate and kinetics, and impact on the cancer cell genome. In addition, I have expanded my research to include all of the available cancer types represented in the publicly accessible portion of The Cancer Genome Atlas (TCGA). Using the massive data repository, I have found that the same mutational phenomenon that I have identified in breast cancer is also at work in 5 other types of cancer: head & neck cancer, cervical cancer, bladder cancer, squamous cell lung cancer and lung adenocarcinomas.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2013
- Accession Number
- ADA591365
Entities
People
- Michael B Burns
Organizations
- University of Minnesota