Protocol Development and Preliminary Toxicity Study of CBRN Nanomaterials

Abstract

This project uses fast, high-throughput in vitro approach to study new nanomaterials applicable to Chemical Biological Defense (CBD) for their environmental and human related toxicity. Four CBD nanomaterials were evaluated for their aquatic toxicity by Microtox test and human cytotoxicity by NRU assay. These studies fill the data gaps and provide toxicity information useful in risk assessment when the environmental and human exposure to these new CBD nanomaterials. In addition, Transepithelial Electrical Resistance (TER) and Transepithelial Permeability (TEP) assays were developed and tested on EpiAirway, a 3-D human tracheal/bronchial epithelial equivalent. Further evaluation of the effects of these CBD nanomaterials on tissue tight junction and barrier function is the on-going study. This project supports the efforts of USAPHC/OTSG in CBRN incident response for protecting the work force, civilian and military, from the unintended consequences of nanotechnology processes and materials exposure.

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Document Details

Document Type
Technical Report
Publication Date
Dec 05, 2013
Accession Number
ADA591771

Entities

People

  • Cheng J. Cao

Organizations

  • United States Army Public Health Command

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Data Analysis
  • Ecotoxicology
  • Electrical Resistance
  • Environment
  • Environmental Health
  • Environmental Protection
  • Intercellular Junctions
  • Materials
  • Nanomaterials
  • Nanotechnology
  • Test Methods
  • Three Dimensional
  • Toxicity

Readers

  • Critical Infrastructure Protection in CBRN and WMD Threats.
  • Nanoscale Plasmonic Nanotechnology
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology