tRNA and Its Activation Targets as Biomarkers and Regulators of Breast Cancer
Abstract
Transfer RNAs (tRNAs) are small non-coding RNAs that read the genetic code in protein synthesis. They are essential for the proliferation, fitness, and adaptation of the cell. Previously, we showed that elevated tRNA levels are characteristic of breast cancer cells (Pavon-Eternod, M., Gomes, S., Geslain, R., Dai, Q., Rosner, M.R. and Pan, T. (2009) tRNA over-expression in breast cancer and functional consequences. Nucleic Acids Res, 37, 7268-7280). Furthermore, overexpression of one specific tRNA - the initiator methionine tRNA - leads to increased cell proliferation and altered tRNA expression in a non-cancer breast epithelial cell line. Based on these results, we hypothesized that tRNA over-expression alters the translational regulation of key genes involved in cancer development and progression. We aim to identify the protein or RNA targets that are mis-regulated upon tRNA over-expression, and to determine the effect of tRNA over-expression on tumor initiation and progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2013
- Accession Number
- ADA591963
Entities
People
- Donghui Zhou
- Guanquan Zheng
- Jiyong Lee
- Mariana P. Eternod
- Marsha Rosner
- Susanna Gomes
- Tao Pan
- Thomas Jones
Organizations
- University of Chicago