Theory-Driven Models for Correcting Fight or Flight Imbalance in Gulf War Illness

Abstract

The objective of this study is to create a comprehensive engineering model of endocrine-immune interaction dynamics in order to identify (i) theoretical failure modes of the HPA-immune axis that align with GWI, and (ii) promising treatment strategies that exploit the regulatory dynamics of these systems to reset control of the HPA-immune axis to normal. We are currently transferring operations and this award to Nova Southeastern University, FL, to facilitate interactions with U.S. sponsors and collaborators. Dr. Craddock, now assistant professor at Nova, will continue in his role on this project. Work has focused on the refinement of the HPA-HPG-immune multi-axis model, its validation scheme and inclusion of Th17 and neurotranmission (NPY, acetylcholine, etc )in the detailed immune model. Importantly we have developed an advanced prototype of a neuroinflammation model. Deployment to large-scale distributed computing platform has also advanced significantly.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA591971

Entities

People

  • Gordon Broderick

Organizations

  • University of Alberta

Tags

Communities of Interest

  • Energy and Power Technologies
  • Human Systems

DTIC Thesaurus Topics

  • Agent-Based Simulations
  • Brain
  • Cardiovascular System
  • Cells
  • Chemistry
  • Chronic Fatigue Syndrome
  • Computational Science
  • Depression
  • Endocrine Glands
  • Health Services
  • Lymphocytes
  • Mathematical Models
  • Medical Personnel
  • Pituitary And Hypothalamic Hormones And Analogues
  • Systems Biology

Readers

  • Computational Modeling and Simulation
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Technical Research and Report Writing.