Targeted Magnetic Hyperthermia for Lung Cancer
Abstract
The hypothesis of this research is that inhalable SPIO nanoparticles surface-functionalized with EGFR targeting ligand, when exposed to an appropriate magnetic field, will enable highly efficient and specific tumor cell death by hyperthermia. In the third year of this three year research program (now with an additional year of no-cost extension), we have demonstrated effective inhibition of tumor growth with EGFR-targeted SPIO particle-mediated magnetic hyperthermia in an orthotopic mouse tumor model. Future studies will examine the effect of targeted SPIO particle-mediated hyperthermia on HSP70 expression in a lung tumor model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2013
- Accession Number
- ADA592043
Entities
People
- Jayanth Panyam
Organizations
- University of Minnesota