Characterization and Optimization of Auto-Transplantation and Allo-transplantation of Free Composite Tissue for Reconstruction of Battlefield Injuries

Abstract

This study is designed to validate the feasibility of gracilis myocutaneous flap transplantation via microvascular free tissue transfer in a porcine model. This model will facilitate study of autotransplant physiology as well as vascularized composite allotransplantation as an evolving method for reconstructing previously nonreconstructable injuries. Assays for skeletal muscle tissue injury (LDH, CK, and AST) showed ischemia period-dependent response providing assessment of ischemiareperfusion injury at the cellular level. Subsequent studies will evaluate agents that mitigate ischemia-reperfusion injury and transition these findings to potentiate vascularized composite allotransplantation.

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Document Details

Document Type
Technical Report
Publication Date
Jan 10, 2014
Accession Number
ADA592171

Entities

People

  • C. Y. Villamaria
  • J. R. Spencer
  • M. R. Davis
  • Sahil Patel
  • T. E. Rasmussen

Organizations

  • 59th Medical Wing

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Afghanistan Conflict
  • Allografts
  • Anesthesia
  • Arteries
  • Blood
  • Body Regions
  • Cardiovascular Physiological Phenomena
  • Chemistry
  • Jugular Vein
  • Laboratory Animals
  • Military Medicine
  • Patient Care
  • Physiology
  • Skeletal Muscle
  • Surgically-Created Structures
  • Vascular Diseases
  • Veins

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Immunology and Pathology
  • Neuroscience

Technology Areas

  • Biotechnology