Evaluation of the Human/Extreme Environment Interaction: Implications for Enhancing Operational Performance and Recovery

Abstract

The purpose of this research determines how hypoxia interacts with exercise and recovery to yield various metabolic responses that may affect performance and performance at high-altitude critical to mission success. Participants completed two maximal exercise tests under hypoxia, 3000 m and normoxic, 975 m conditions. Three experimental trials were then completed [hypoxia, 3000m at 60% of their hypoxic peak power (HH); normoxia, 975m at 60% of their hypoxic peak power (NH); and normoxia at 60% of their normoxic peak power (NN)] using a randomized, counterbalanced cross-over design over the span of 3 weeks, with a minimum of 7 days between trials. Our initial findings demonstrate that exercise during hypoxia (3000 m) and normoxia (975 m) results in similar responses (glycolytic, metabolic, and mitochondrial morphology genes, and oxidative stress markers) when the exercise intensity is clamped relative to the specific environment (as a % of either hypoxic or normoxic peak power). There were subtle differences in the glycogen response to exercise/recovery, which is likely a function of the higher absolute workrate during the NN trial. These results demonstrate similar response patterns across the three trials and suggest the need for a more aggressive degree of hypoxia to establish differences in the metabolic gene and oxidative stress marker responses.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2011
Accession Number
ADA592672

Entities

People

  • Brent C. Ruby

Organizations

  • University of Montana

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Altitude
  • Biological Factors
  • Biomedical Research
  • Blood
  • Cells
  • Chemistry
  • Environment
  • Free Radicals
  • Glycogen
  • High Altitude
  • Institutional Review Board
  • Mitochondria
  • Oxidative Stress
  • Peak Power
  • Peptides
  • Proteins
  • Skeletal Muscle

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Exercise and Sports Science.
  • Molecular and Cellular Biology