Evaluation of the Human/Extreme Environment Interaction: Implications for Enhancing Operational Performance and Recovery
Abstract
The purpose of this research determines how hypoxia interacts with exercise and recovery to yield various metabolic responses that may affect performance and performance at high-altitude critical to mission success. Participants (n=10) completed two exercise trials under normoxic conditions (975 m) that included a 90-minute interval protocol (cycling). Subjects then recovered for 4 hours under the same normoxic conditions or at a high, simulated altitude of 5000 m. Muscle biopsies from the vastus lateralis were obtained before exercise, after exercise and 6 hours after exercise for the measurement of metabolic gene expression and muscle glycogen. Muscle glycogen decreased with exercise and increased with recovery with no difference between trials. The majority of the metabolic genes were suppressed after altitude exposure. These data demonstrate that high altitude exposure during recovery from exercise inhibits gene expression associated with mitochondrial development without affecting the recovery of muscle fuels.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2012
- Accession Number
- ADA592673
Entities
People
- Brent C. Ruby
Organizations
- University of Montana