Impact of Contextual Factors on Prostate Cancer Risk and Outcomes
Abstract
During this reporting period, we have focused on completing the proposed case-control and survival analyses corresponding to Specific Aims 1 and 2. We have found a nearly 1.5-fold increased rate of death among cases living in the lowest neighborhood socioeconomic status (SES) quintile compared to those in the highest quintile; individual-level education and other prognostic factors did not impact these associations. With regards to prostate cancer risk, we found a two-fold increase in the odds of both localized and advanced prostate cancer comparing the lowest to highest neighborhood SES quintiles; individual-level education and other prostate cancer risk factors did not impact these associations. The addition of distinct neighborhood factors (population density, traffic density, residential mobility, and the retail food environment) did little to mediate the effects of neighborhood SES on survival, but resulted in a mediating effect on risk both education and neighborhood SES among localized cases, but not among the advanced cases. We have recently received approval for a 9-month no-cost extension and will be focusing on writing up these results in scientific manuscripts.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2013
- Accession Number
- ADA592798
Entities
People
- Scarlett L. Gomez
Organizations
- Cancer Prevention Institute of California