Minocycline and N-acetylcysteine: A Synergistic Drug Combination to Treat Traumatic Brain Injury
Abstract
Due to the changing nature of war, there is a pressing need for new treatments for traumatic brain injury (TBI). The grantee previously found screened that the combination of minocycline (MINO) and N-acetyl cysteine (NAC) synergistically improved brain function when dosed one hour following closed cortical impact (CCI) in rats. The overall objective of this proposal is that MINO/NAC synergistically improves brain function following TBI. Three tasks will be done to achieve this objective: 1) Differing doses of MINO/NAC will be tested for the ability to improve behavior and histology following closed head injury in mice (CHI). 2) MINO/NAC was effective when dosed one hour after injury. Longer intervals between injury and drug dosing will be tested. 3) A restoration of cognitive function will be tested three months after CHI. The grantee has shown that MINO plus NAC improves cognition in two models of TBI, a single impact closed head injury (CHI) in mice and the CCI model in rats. The drug combination improves cognition and limits white matter injury in two models and two species. These data attest to the potency of the drug combination.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA592920
Entities
People
- Peter Bergold
Organizations
- State University of New York