Early Detection of Breast Cancer Using Posttranslationally Modified Biomarkers

Abstract

In this project, we focus on oxidation and glycosylation PTMs on proteins known to be secreted by the breast as candidate biomarkers for the early detection of breast cancer. ELISA microarray technology has employed to evaluate assays that have potential be used as breast cancer biomarkers. During the third year of this project we have continued the validation for our PTM-ELISA microarray. And we validated the chosen PTM antibody for pre-clinical or translational molecular imaging studies. The microPET imaging suggested that those PTM antibodies have high specific accumulation for breast cancer in tumor xenograft mice. Overall, our data suggest that the PTM ELISA microarray platform is a promising tool for discovery and evaluation of biomarkers that have potential for the early detection of breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA592990

Entities

People

  • Hongjun Jin

Organizations

  • Battelle Memorial Institute

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biomedical And Dental Materials
  • Blood
  • Breast Cancer
  • Cells
  • Chemistry
  • Colon Cancer
  • Medical Personnel
  • Peptide Growth Factors
  • Peptides
  • Polymeric Films
  • Prostate Cancer
  • Proteins
  • Proteomics
  • Tumor Cell Line
  • Vaccines

Readers

  • Medical Imaging.
  • Oncology and Biomarker-Based Cancer Detection.