Marrow-Derived Antibody Library for Treatment of Neuroblastoma

Abstract

Neuroblastoma (NB) is the most common solid tumor in children, which accounts for 15% of all pediatric cancer deaths in the US. New therapeutic antibodies to treat NB are urgently needed to improve survival. The purpose of this project is to produce patient-specific therapeutic antibodies to treat neuroblastoma. The goal is to develop new methods and strategies to capture the auto-immune response reaction in neuroblastoma patients using phage display and B cell hybridoma technologies. The scope of this project is to use NB patient-derived materials to create NB cell lines, xenograft models, NB specific phage display libraries and to identify and amplify functional anti-NB specific antibodies for future therapeutic intent.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA593124

Entities

People

  • Giselle Sholler

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Bone Marrow
  • Cell Line
  • Cells
  • Cultured Cells
  • Health Services
  • Materials
  • Neoplasms
  • Neuroblastoma
  • Surgery
  • Xenografts

Fields of Study

  • Medicine

Readers

  • Immunology
  • Oncology
  • Positioning, Navigation, and Timing (PNT) Technology.