Prospective Evaluation of Intraprostatic Inflammation and Focal Atrophy as a Predictor of Risk of High-Grade Prostate Cancer and Recurrence after Prostatectomy
Abstract
We are evaluating, in two nested case-control studies, intraprostatic inflammation and focal atrophy, a prostate lesion that is often inflamed, as tissue markers for risk of future diagnosis of high-grade prostate cancer, and for prognosis at the time of surgery for clinically localized prostate cancer. For prostate cancer incidence, in Year 1, we developed the source population, prostate cancer case, and control definitions for this work, selected all prostate cancer cases and 2 controls per case who were frequency matched on age, race, and treatment arms for the two trials. We pulled prostate biopsy tissue samples from the PCPT biorepository and cut and mounted sections from paraffin-embedded prostate tissue biopsy core per man onto slides. We imaged H&E stained section of prostate tissue biopsy cores and uploaded the images for remote review. For prostate cancer recurrence, in Year 1, we pulled the recurrence TMAs, cut and mounted TMA sections, and H&E stained them. We have optimized the IHC staining for the immune markers for the prostate tissue biopsies and are doing the same for the recurrence TMAs. Our work is progressing per the Statement of Work.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2013
- Accession Number
- ADA593262
Entities
People
- Elizabeth A Platz
Organizations
- Johns Hopkins University