Salivary Proteomic and microRNA Biomarkers Development for Lung Cancer Detection

Abstract

This is a lung cancer biomarker development project to test the hypothesis that there are discriminatory proteomic and miRNA biomarkers in saliva that can detect lung cancer with the aim to reduce the number unnecessary diagnostic workups (bronchoscopy) in patients with suspicious chest symptoms. Preliminary data is in place to support that our salivary biomarker technologies can discover and validate lung cancer biomarkers in saliva. The major goal is to perform a properly powered biomarker discovery and definitive validation of salivary proteomic and miRNA biomarkers for detection of lung cancer based on PRoBE design principles (prospective-specimen-collection and retrospective-blinded-evaluation). The outcome of this three-year proposal will be a panel of definitively validated non-invasive saliva-based proteomic and micro-RNA biomarkers for detection of lung cancer.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2013
Accession Number
ADA593384

Entities

People

  • David Wong

Organizations

  • University of California, Los Angeles

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biological Markers
  • Biomedical Research
  • California
  • Cancer
  • Department Of Defense
  • Detection
  • Diseases And Disorders
  • Electronic Mail
  • Information Operations
  • Lung Cancer
  • Neoplasms
  • Universities

Fields of Study

  • Medicine

Readers

  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology