The Role of Microglial Subsets in Regulating Traumatic Brain Injury

Abstract

Microglia are the innate immune cells of the brian. They share cell lineage with macrophages, which have been divided into two major subgroups: (i) classical or "M1" macrophages, which promote inflammation and express IL-12, and (ii) alternatively activated or "M2" macrophages, which engulf apoptotic cells, promote wound repair, and (in mice) express arginase-1. We proposed that microglia might be also reflect these functional subsets and that activation of microglia by TBI would be determental to the extent that it involved M1-like (pro-inflammatory) microglia, but beneficial to the extent that it involves the activation of M2-like (reparative) microglia.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2013
Accession Number
ADA593730

Entities

People

  • William E. Seaman

Organizations

  • Northern California Institute for Research and Education

Tags

DTIC Thesaurus Topics

  • Blood
  • Boundaries
  • Brain Injuries
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Cytokines
  • Department Of Defense
  • Department Of Veterans Affairs
  • Gene Expression
  • Granulocytes
  • Histology
  • Leukocytes
  • Lymphocytes
  • Medical Personnel
  • Microscopy
  • Surgery

Fields of Study

  • Biology

Readers

  • Immunology and Pathology