SOX9 Is a Progressive Factor in Prostate Cancer

Abstract

The purpose of this proposal is to test the hypothesis that SOX9 contributes to prostate cancer (PCa) progression by supporting the cancer stem cells (CSC). The results have demonstrated that SOX9 is enriched in prostate CSC. SOX9 silencing leads to reduced CSC population. Cells with higher SOX9 activity (as indicated by an activity reporter) have greater tumoreigenecity. Overall, it has been established that SOX9 plays critical role in prostate progression by supporting the CSCs and may serve as a new biomarker and therapeutic target.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA593774

Entities

People

  • Xin Yuan

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Genetics
  • Health Services
  • Intestines
  • Medical Personnel
  • Neoplasms
  • Prostate Cancer
  • Stem Cells
  • Therapy
  • Tissues

Readers

  • Aerospace Engineering
  • Software Engineering.
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Technology Areas

  • Biotechnology