Photonic Breast Tomography and Tumor Aggressiveness Assessment
Abstract
The tasks performed and the progress made in the project included carrying out research on developing non-invasive near infrared (NIR) diffuse optical imaging (DOI) approaches for detection of breast tumors in early stages of growth when those are more amenable to treatment, and developing a training program for physical scientists in biological aspects of cancer research. In particular, the following NIR-DOI approaches for locating absorbing, scattering and fluorescent targets, and estimating their size and optical properties were developed and evaluated: (i) time reversal optical tomography (TROT); (ii) optical tomography based on Non-negative Matrix Factorization (NMF-OT), and Principal Component Analysis (PCA-OT). Previously developed OT based on Independent Component Analysis (Optica) was further extended. The work on Trot was highlighted in "Optics in 2012," a special issue of the Optics and Photonics News as one of the 30 "most exciting peer-reviewed optics research to have emerged over the past 12 months." A graduate student working on the project defended his Ph.D. thesis.. The results were disseminated in several publications and presentations. Several research proposals and pre-proposals were submitted. A breast cancer research program has been established at CCNY, a minority institution.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2013
- Accession Number
- ADA593928
Entities
People
- Binlin Wu
- F. B. Lin
- J. A. Koutcher
- M. Alrubaiee
- R. R. Alfano
- Swapan K. Gayen
Organizations
- City University of New York