Identification of Genes and Genetic Variants Associated with Poor Treatment Response in Patients with Prostate Cancer
Abstract
Our initial linkage analysis identified a significant linkage on chromosome 11 and a manuscript is in preparation. We will now collaborate (with other funding) to begin sequence analysis of the regions of interest. We have expanded our identification of high-risk pedigrees and identified an additional 192 samples in new high risk pedigrees soon to be genotyped. Some of these samples extend previously identified pedigrees with linkage evidence. We have begun sequence analysis of 34 lethal prostate cancer cases and identified a set of candidate genes in a set of 6 pairs of lethal prostate cancer cases sequenced. Identification of genes predisposing to recurrent/lethal prostate cancer from this study will validate this powerful approach, which can be extended to other high risk prostate cancer pedigrees, and will identify genes and pathways that can be further examined to expand our knowledge of prostate cancer genetics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA594134
Entities
People
- Craig Teerlink
- Lisa Cannon-Albright
- Neeraj Agarwal
Organizations
- University of Utah