Role of NF-Kappa B Signaling in X-Box Binding Protein 1 (XBP1)-Mediated Antiestrogen Resistance in Breast Cancer

Abstract

Breast cancer is the most common cancer type among women, with 70% of the patients is estrogen receptor positive (ER+) and receives endocrine therapy (1). However, most patients develop antiestrogen resistance after long-term exposure. Overcome antiestrogen resistance will significantly improve the long-term treatment outcome of ER+ breast cancer patients. XBP1 is a known factor that promotes antiestrogen resistance in breast cancer (2-3). The overall hypothesis of this grant is that NFkB signaling is downstream of XBP1 pathway and is essential for XBP1 mediated antiestrogen resistance in breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA594159

Entities

People

  • Rong Hu

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Autophagy
  • Biology
  • Breast Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Department Of Defense
  • Endoplasmic Reticulum
  • Estrogens
  • Inhibition
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Students

Readers

  • Breast cancer cell signaling and growth regulation.
  • Coastal and Marine Engineering/Sediment Transport/Hydraulic Engineering
  • Oncology