Imaging Prostatic Lipids to Distinguish Aggressive Prostate Cancer
Abstract
In this application, we propose to build upon our current work to determine the association between fatty acid synthase (FAS) overexpression and intraprostatic fat as measured by in-vivo imaging using proton magnetic resonance spectroscopy imaging in the prediction of prostate disease aggressiveness. Mechanisms linking fatty acid synthase overexpression, lipid accumulation, lipid oxidation, and tumor aggressiveness will be explored using metabolomics. Plan: Employing a cross-sectional design we will recruit 50 men with lowgrade and 50 men with high grade prostate cancer post-diagnosis as determined prior to prostatectomy. Each patient will complete one proton magnetic resonance spectroscopy imaging session and provide access to his prostatectomy tissue.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2013
- Accession Number
- ADA594175
Entities
People
- Jackilen Shannon
Organizations
- Oregon Health & Science University