Innovative Strategies for Breast Cancer Immunotherapy

Abstract

In our grant application, we detected HERV-K viral particles by transmission electron microscopy (TEM) in sera from an invasive ductal carcinoma (IDC) patient and in BC cell culture media. In fact, HERV-K viral like particles have been found in a variety of tumor cells, as reported by others. These viral particles would be expected to have RT activity. The RT activity of various breast cell culture media was compared, and we found that all cancer cells had higher RT, compared with MCF-10AT cells. In addition, two IBC cell lines (KPL-4 and SUM149) had increased RT activity.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA594297

Entities

People

  • Feng Wang-johanning

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Blood
  • Breast Cancer
  • Carcinoma
  • Cell Line
  • Cells
  • Culture Media
  • Culture Techniques
  • Diseases And Disorders
  • Electron Microscopy
  • Immunotherapy
  • Lymphocytes
  • Microscopes
  • Microscopy
  • Neoplasms
  • Transmission Electron Microscopy
  • Viral Load
  • Virion

Fields of Study

  • Biology

Readers

  • Aerosol Science/Aerosol Physics
  • Immunology
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology
  • Microelectronics