Development and Efficacy Testing of Next Generation Cyanide Antidotes

Abstract

This proposal addresses the intent of the NIH CounterACT Program to reduce mortality and morbidity resulting from the release of chemical threats such as CN. Since the onset of CN toxicity is rapid, the prognosis of a victim depends on the immediate and aggressive application of a safe, efficacious, rapidly acting, and easily administered antidote. The major purpose of this project is to develop an efficient, easy to administer (i.e., intramuscular; IM) sulfur-donor-based CN countermeasure, which may also be used in combination with other countermeasures (e.g., cobinamide and sulfanegen, which are currently under development). Preliminary in vivo efficacy studies from our laboratory indicate that dimethyl trisulfide (DMTS), a naturally occurring component of garlic and generally recognized as safe as a flavor enhancer by the FDA, is a promising SD effective in countering CN toxicity.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA594849

Entities

People

  • Ilona Petrikovics

Organizations

  • Sam Houston State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antidotes
  • Aqueous Solutions
  • Blood
  • Cells
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Detectors
  • Dosage Forms
  • Gas Chromatography
  • Health Services
  • Liquid Chromatography
  • Mass Spectrometry
  • Measurement
  • Organic Chemistry
  • Spectrometry
  • Toxicity

Readers

  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology