The Use of Drugs to Reduce Hearing Loss Following Acute Acoustic Trauma
Abstract
The goal of this research was to compare, in the rescue mode of treatment, the effectiveness of (1) L-N-acetylcysteine (L-NAC); (2) D-Methionine (D-MET); (3) Ebselen SPI-1005; (4) Acetyl-L-carnitine (ALCAR) and (5) Src-PTK inhibitor, KX1-004 in reducing hearing and sensory cell loss as the result of an acute acoustic trauma that simulates blast injury to the auditory system. A shock tube was used to produce a blast injury to the cochlea in a chinchilla model. A secondary goal was to apply the same drug administration protocol to groups of animals exposed to a lower level continuous noise. Data from the treated and control animals consisted of: (1) auditory evoked potential hearing thresholds; (2) cubic distortion product otoacoustic emissions (DPOAE) input/output functions along with DPOAEs as a function of frequency (DPEgram) to estimate sensory cell function; (3) tympanograms to screen for conductive changes; (4) surface preparation histology to estimate the frequency specific sensory cell loss. Statistical analysis of the data employed a mixed model analyses of variance with repeated measures on one factor (frequency) using the SPSS Release 4.0 statistical package. Results: (1) There were no statistically significant differences between drug treated groups and controls. (2) There was a very large inter subject variability for all exposure groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 15, 2013
- Accession Number
- ADA594873
Entities
People
- Roger P. Hamernik
Organizations
- State University of New York at Plattsburgh