Development of Targeted Nanobubbles for Ultrasound Imaging and Ablation of Metastatic Prostate Cancer Lesions

Abstract

We report the synthesis of the amphiphilic PEG-b (PAA)-b-P(HDFMA-co-MMA) copolymers that proved to encapsulate 1%-2% v/v PFP forming nanodroplets. Combining these nanodroplets with histotripsy proved to generate a cavitation bubble cloud with similar behavior but lower pressure compared to histotripsy itself. Moreover, these nanodroplets maintained their average size and concentration upon incubation with BSA for 24 hours at 37 degrees celcius, which prove their promise for cancer cell ablation and warrant their future testing in vivo.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2013
Accession Number
ADA594876

Entities

People

  • Mohamed El-sayed

Organizations

  • University of Michigan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Ablation
  • Alkenes
  • Block Copolymers
  • Blood
  • Blood Cells
  • Chemical Synthesis
  • Chemistry
  • Copolymers
  • Electron Microscopes
  • Glass Transition Temperature
  • Neoplasms
  • Organic Chemistry
  • Phase Transformations
  • Polymers
  • Prostate Cancer
  • Sodium Compounds
  • Transition Temperature

Readers

  • Medical Imaging.
  • Thermal Physics or Thermal Science.
  • Underwater engineering and Marine Technology.

Technology Areas

  • Microelectronics