Identification of Small Molecule Inhibitors of microRNA Involved in Chemoresistance and Cancer Stem Cells for Ovarian Cancer Intervention

Abstract

During last year, we have characterized a small molecule inhibitor (MIR214-I) of miR-214. MIR214-I was found to specifically bind to miR-214 in vitro and in vivo. Furthermore, MIR214-I induces programmed cell death and inhibits ovarian cancer stem cell renewal in ovarian cancer cells expressing high levels of miR-214. In addition, MIR214-I selectively reduces tumor growth in xenograft model. Notably, MIR214-I synergizes with cisplatin and overcomes cisplatin resistance.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA595907

Entities

People

  • Jin Cheng

Organizations

  • H. Lee Moffitt Cancer Center & Research Institute

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Inhibitors
  • Lung Cancer
  • Migration
  • Molecules
  • Neoplasms
  • Ovarian Cancer
  • Polysaccharides
  • Small Molecules
  • Stem Cells

Fields of Study

  • Biology
  • Chemistry

Readers

  • Immunology and Pathology
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech