Immunomodulation to Optimize Vascularized Composite Allograft Integration in Limb Loss Therapy

Abstract

Recent improvements in body armor have reduced the rate of combat death but increased the rate of extremity injury, burn and limb loss in surviving casualties. As such, methods to replace injured limbs are increasingly required to support combat service personnel. Vascularized composite all transplantation (VCA) has recently emerged as a promising strategy for the repair or replacement of amputated limbs, and novel methods for immune management to prevent the rejection of transplanted tissues are now available that may greatly reduce the risks associated with limb transplantation.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA596553

Entities

People

  • Linda C. Cendales

Organizations

  • Emory University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allografts
  • Anatomy
  • Armor
  • Biological Sciences
  • Biomedical Research
  • Body Armor
  • Casualties
  • Composite Materials
  • Department Of Defense
  • Immunomodulation
  • Institutional Review Board
  • Management Personnel
  • Medical Personnel
  • Rejection
  • Therapy
  • Transplantation
  • Transplants

Fields of Study

  • Medicine

Readers

  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology