Odor Signals of Immune Activation and CNS Inflammation
Abstract
We tested the hypothesis that inflammation results in detectable alteration of body odors. Using an animal model, we trained biosensor mice to distinguish between urine odors from lipopolysaccharide-treated and control mice. Lipopolysaccharide (LPS) is a general elicitor of inflammation. Trained biosensors could distinguish between the odors of LPS-treated and control mouse urine. Chemical analyses further demonstrated that LPS-induced inflammation results in alteration of urine volatiles. Importantly, urine samples collected many days following LPS-administration were discriminable. Thus, odor differences were not produced by acute effects of LPS-treatment (e.g. dehydration); nor were they likely related to changes in cytokines which usually occur within hours of LPS exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 15, 2013
- Accession Number
- ADA596566
Entities
People
- Gary Beauchamp
Organizations
- Monell Chemical Senses Center