Translational Pharmacologic Efficacy Studies of Glial Growth Factor 2 (GGF2) in Spinal Cord Injury Models and in the Veterinary Clinical Setting

Abstract

The goals of our studies in year 2 were to (a) use the most effective dosages and route of administration of GGF2 on the proliferation of NG2-expressing glia cells after SCI that we identified in year 1 in long term studies of effects on functional recovery and chronic histopathology and (b) subject spinal cords from some of these rats to MRI and Diffusion Tensor Imaging (DTI) of the spinal cord to develop MRI imaging method that can detect treatment effects that improve survival and myelination of axons after SCI for potential use in future dog studies.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA596747

Entities

People

  • Anindita Ganguly
  • Anthony O. Caggiano

Tags

DTIC Thesaurus Topics

  • Analysis Of Variance
  • Biomedical Research
  • Body Weight
  • Compression
  • Diseases And Disorders
  • Growth Factors
  • High Resolution
  • Locomotion
  • Maintenance
  • Muscles
  • Recovery
  • Skeletal Muscle
  • Sodium Azides
  • Spinal Cord
  • Spinal Injuries
  • Surgery
  • Urinary Tract

Readers

  • Neuroscience