High-Throughput Screening of Compounds for Anti-Transmissible Spongiform Encephalopathy Activity Using Cell-Culture and Cell-Free Models and Infected Animals
Abstract
Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal, transmissible and untreatable neurodegenerative diseases of humans and animals. To aid in the search for anti-TSE therapeutics, we have: (1) developed new relatively high through-put in vitro drug screens, (2) assayed large numbers of previously untested compounds as TSE inhibitors, (3) identified numerous new prion/PrP(Sc) inhibitors in vitro and in vivo, and (4) developed a new unified mechanistic model for the activity of various classes of PrPSc inhibitors which is consistent with a considerable body of evidence from our laboratory and others.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2008
- Accession Number
- ADA596894
Entities
People
- Byron Caughey
- David Kocisko
Organizations
- National Institute of Allergy and Infectious Diseases