Repeated-Dose and Reproductive/Developmental Toxicity of NTO (3-Nitro-1,2,4-Triazol-5-One) in the Rat
Abstract
Male and female Sprague-Dawley rats were administered NTO in corn oil (0, 31.25, 125, and 500 mg/kg-day) via oral gavage for two weeks prior to mating and for an additional two weeks during mating. Female rats were dosed throughout gestation and for four days following birth. Two male recovery groups (0 and 500 mg/kg-day) were held for four weeks following the four-week dosing period. Reductions in testes and epididymal mass and mass ratios were observed in the 500 mg/g-day group compared to controls. Sperm counts were also reduced in the 500 mg/kg-day group compared to controls with no motile sperm observed. The reductions in testes and epididymal mass were associated with tubular degeneration/atrophy and hypospermia with cribiform change of the epididymides. Complete recovery was not evident in the 500 mg/kg-day recovery group. No discernable differences were recognized between dose groups for the reproductive parameters monitored. Gross external examinations of the offspring did not indicate that NTO presents a developmental hazard.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 21, 2014
- Accession Number
- ADA597490
Entities
People
- Emily M. Lent
- Lee C. Crouse
Organizations
- United States Army Public Health Command