Microtubule Control of Metabolism in Prostate Cancer

Abstract

We tested whether metabolic inhibitors, metformin or 2-deoxy-glucose, function synergistically with docetaxel to block prostate cancer cell proliferation. Cell proliferation curves allowed calculation of the combination index, a quantitative measure of drug interactions, for LNCaP or PC-3 cell lines. Data trended toward synergy between microtubule-targeted drugs and metabolic inhibitors. Synergy was consistently calculated at the ED50 for each drug, but the combination index often shifted toward antagonism at higher drug doses. Statistical analyses indicated that some drug combination data were not significantly different from either drug alone, reducing confidence in the overall conclusion of synergy.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2013
Accession Number
ADA597853

Entities

People

  • Lynne Cassimeris

Organizations

  • Lehigh University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Azo Compounds
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Confocal Microscopy
  • Culture Techniques
  • Drug Combinations
  • Epithelial Cells
  • Inhibition
  • Inhibitors
  • Metabolism
  • Neoplasms
  • Prostate Cancer
  • Statistical Analysis
  • United States

Fields of Study

  • Biology
  • Chemistry

Readers

  • Oncology (Cancer Research).
  • Prostate Cancer Biology.
  • Regression Analysis.