Overcoming Autophagy to Induce Apoptosis in Castration-Resistant Prostate Cancer
Abstract
Survival mechanisms elicited by CRPC C4-2B cells when treated with Enza may be blocked by inhibiting autophagy with clomipramine and metformin. Combination of Enza with saracatinib and autophagy modulators significantly reduced cell proliferation in the LNCaP GRP CRPC model. Further in vivo studies will provide evidences to make autophagy targeting as a supplement to cancer therapeutic regimes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA597874
Entities
People
- Christopher P Evans
Organizations
- University of California