Nicotinic Receptor Polymorphism in Lung Cancer

Abstract

The purpose of this study was to identify the genetic polymorphisms in nicotinic acetylcholine (ACh) receptors (nAChRs) that modify the risk for non-small cell lung carcinoma (NSCLC). The proposal addressed two areas of emphasis: 1) understanding the molecular mechanisms that lead to clinically significant lung cancer; and 2) identification of the mechanisms that lead to the development of the various types of lung cancer. This application was based upon our recent discoveries of both positive and negative associations of single nucleotide polymorphisms (SNPs) of certain nAChR subunits with NSCLC, and the ability to mutant receptors to increase or decrease susceptibility of bronchial cells to the tobacco nitrosamine-induced carcinogenic transformation of human bronchial cells [1-2].

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA598342

Entities

People

  • Sergei Grando

Organizations

  • University of California, Irvine

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Cancer
  • Cells
  • Chemical Compounds
  • Department Of Defense
  • Electronic Mail
  • Genetic Phenomena
  • Genetic Variation
  • Genomics
  • Identification
  • Information Operations
  • Lung Cancer
  • Neoplasms
  • Nitroso Compounds
  • Nucleotides
  • Pilot Studies

Fields of Study

  • Biology
  • Chemistry

Readers

  • Immunology and Pathology
  • Molecular and genetic basis of cancer.
  • Neuroscience

Technology Areas

  • Biotechnology