A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

Abstract

A small, lightweight microdevice has been developed for activity-dependent stimulation (ADS) and successfully tested for functionality in both anesthetized and ambulatory rats. Further, in semi-chronic experiments in rats with traumatic brain injury (TBI) using this microsystem, an unprecedented, potent effect of ADS on motor performance has been demonstrated, as compared to control rats (injured but no microdevice) and open-loop stimulation (OLS) rats. Specifically, OLS does result in some recovery after injury, but ADS is significantly more efficacious, resulting in recovery to normal ranges of performance within 2 weeks after injury.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA598378

Entities

People

  • Pedram Mohseni

Organizations

  • Case Western Reserve University

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Accuracy
  • Algorithms
  • Biology
  • Brain Injuries
  • Computer Science
  • Digital Signal Processing
  • Dynamic Range
  • Electrical Engineering
  • Engineering
  • Field Programmable Gate Arrays
  • Frequency
  • Medical Personnel
  • Neural Engineering
  • Recovery
  • Rodents
  • Signal Processing
  • Steady State

Fields of Study

  • Biology

Readers

  • Computer Networking
  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.