A Brain-Machine-Brain Interface for Rewiring of Cortical Circuitry after Traumatic Brain Injury

Abstract

A small, lightweight microdevice has been developed for activity-dependent stimulation (ADS) and successfully tested for functionality in both anesthetized and ambulatory rats. Further, in semi-chronic experiments in rats with TBI using this microsystem, an unprecedented, potent effect of ADS on motor performance has been demonstrated, as compared to control rats (injured but no microdevice) and open-loop stimulation (OLS) rats. Specifically, open-loop stimulation does result in some recovery after injury, but ADS is significantly more efficacious, resulting in recovery to normal ranges of performance within 2 weeks after injury.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2013
Accession Number
ADA598379

Entities

People

  • Randolph J Nudo

Organizations

  • University of Kansas Medical Center

Tags

DTIC Thesaurus Topics

  • Animals
  • Brain
  • Brain Injuries
  • Cells
  • Cerebral Cortex
  • Closed Loop Systems
  • Cognitive Impairment
  • Department Of Defense
  • Diseases And Disorders
  • Firing Rate
  • Materials
  • Neuroplasticity
  • Neurosciences
  • Prostheses And Implants
  • Recovery
  • Rodents
  • Spinal Cord

Fields of Study

  • Biology

Readers

  • Neuroscience
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.