Targeted Riluzole Delivery by Antioxidant Nanovectors for Treating Amyotrophic Lateral Sclerosis

Abstract

The goal of this proposal is to determine whether hydrophilic carbon clusters (HCCs), that have exhibited potent antioxidant properties, can promote motorneuron integrity and enhance survival in a mouse model of amyotrophic lateral sclerosis. This project involves work performed at both UT-Health and Rice University; combining the cutting edge nanotechnology expertise of Dr. James Tour s laboratory at Rice with Dr. Grill s animal models at UT-Health. We are attempting to, first, determine whether Dr. Tour s HCCs can enhance motoneuron survival as well as overall lifespan in the G93A mouse model of ALS. In addition, we will also determine whether the HCCs, when combined with the current gold standard treatment for ALS, riluzole, will represent a new combinatorial therapy to improve outcome for patients living with ALS.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA598451

Entities

People

  • Raymond J. Grill

Organizations

  • University of Texas Health Science Center at Houston

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Antioxidants
  • Biomedical Research
  • Body Weight
  • Buildings And Structures
  • Carbon Nanotubes
  • Combination Therapy
  • Department Of Defense
  • Disease Attributes
  • Electronic Mail
  • Jugular Vein
  • Nanotechnology
  • Sclerosis
  • Standards
  • Survival
  • Universities
  • Veins

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Immunology and Pathology
  • Nanoscale Plasmonic Nanotechnology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech