The Role of Sox2 in Lung Cancer Initiation and Progression

Abstract

The purpose of the proposed research is to clarify the mechanism of Sox2-induced non-small cell lung cancer. The first aim involves investigating p63 as a direct target of Sox2 in tumor cells. The second aim investigates the tumor-initiating ability of proximal and distal respiratory epithelial cells when Sox2 is overexpressed. The third aim tests the hypothesis that strain-specific modifier genes affect the phenotype of mice inducibly overexpressing Sox2 in Scgb1a1-expressing cells. We have continued work on all three aims.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA598798

Entities

People

  • Mark Onaitis

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Chain Reactions
  • Chemical Reactions
  • Connective Tissue
  • Department Of Defense
  • Electronic Mail
  • Epithelial Cells
  • Epithelium
  • Gene Expression
  • Genes
  • Genetics
  • Lung Cancer
  • Neoplasms
  • Polymerase Chain Reaction

Fields of Study

  • Biology
  • Chemistry

Readers

  • Oncology (Cancer Research).