Use of GDNF-Releasing Nanofiber Nerve Guide Conduits for the Repair of Conus Medullaris/Cauda Equina Injury in the Nonhuman Primate
Abstract
Cauda equina and conus medullaris forms of spinal cord injury result in paralysis, sensory impairment, and autonomic dysfunction (Hoang and Havton, 2006; Havton and Carlstedt, 2009). The present study investigates the effects of neural repair in the non-human primate using a GDNF-releasing nerve guidance channel. The studies aim to repair avulsed lumbosacral ventral roots using a bridging strategy. For comparison, the studies will also include the use of a guidance channel without GDNF release and a peripheral nerve graft to bridge the tissue gap. A comprehensive set of electrodiagnostic, imaging, behavioral and anatomical studies will provide detailed information about the outcome of the intervention. We are hopeful that this translational research study may guide planning of future clinical studies on neural repair after cauda equina/conus medullaris injuries. The present report will summarize the major accomplishments within the third year of this 3-year project.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA599060
Entities
People
- Kari Christe
Organizations
- University of California