Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury

Abstract

Severe bone loss commonly occurs in individuals with chronic spinal cord injury who are non weight-bearing and leads to an increased risk of lower extremity fractures. This 12 month multi-side, double-blind, randomized, placebo-controlled study evaluates the efficacy and safety of two interventions known to be anabolic to bone, parathyroid horomone and mechanical loading (provided as teriparatide and vibration respectively). In 60 SCI individuals with low bone mass. At the end of the third year of this project, enrollment has been completed there are 24 participants (40%) who have completed year 1 of the study; 55% of participants are still active during the first year of the study and 5% have elected not to continue. No safety issues have arisen during the course of the study. Results regarding efficacy will only be available at the completion of the trial.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2013
Accession Number
ADA599169

Entities

People

  • Thomas J Schnitzer

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Department Of Defense
  • Information Operations
  • Lower Extremity
  • Musculoskeletal Physiology
  • Osteoporosis
  • Spinal Cord
  • Spinal Injuries
  • Vibration

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.