Aspm, a Key Element in Medulloblastoma Pathogenesis and a Novel Target for Treatment
Abstract
Medulloblastoma is the most common malignant brain tumor in children. We have found that Aspm, a gene required for normal brain growth in early childhood, becomes co-opted during medulloblastoma formation, to support tumor growth. We have found that Aspm supports growth by reducing stress to genomic DNA when cells divide. We have further found that targeting Aspm can reduce medulloblastoma growth.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2013
- Accession Number
- ADA599233
Entities
People
- Idoia Garcia
- Timothy Gershon
Organizations
- University of North Carolina at Chapel Hill