Validating Diagnostic and Screening Procedures for Pre-Motor Parkinson's Disease

Abstract

The goal of this 24-month proposal is to establish the critical infrastructure for the initiation of a five year prospective follow-up study to identify those at risk for developing PD or a related Lewy body disorder in three study populations. The ultimate goal of this work is to develop low-cost non-invasive screening methods to detect pre-motor Parkinson s disease (PD) that can be implemented population-wide. Our hypothesis is that cardiac autonomic dysfunction assessed as heart rate variability (HRV) using a standard EKG, in combination with hyposmia and other simple screening tests, will be highly predictive of abnormalities in DAT imaging and ultimately predict the emergence of full-blown PD or a related Lewy body disorder.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2014
Accession Number
ADA599235

Entities

People

  • J. W. Langston
  • Samuel M. Goldman

Tags

DTIC Thesaurus Topics

  • Abnormalities
  • Biomedical Research
  • Central Nervous System Diseases
  • Data Transmission
  • Dementia
  • Diseases And Disorders
  • Dysfunction
  • Electrocardiography
  • Health Services
  • Heart Rate
  • Infrastructure
  • Institutional Review Board
  • Materials
  • Medical Personnel
  • Parkinson'S Disease
  • Physical Examination (Medicine)
  • Public Health

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Oncology and Biomarker-Based Cancer Detection.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.