Cytokine Response to Subclinical Cytomegalovirus Reactivation as a Cause of Severe Fatigue in Women Undergoing Chemotherapy for Breast Cancer
Abstract
Patients undergoing chemotherapy for breast cancer frequently experience debilitating cancer treatment- related fatigue (CTRF), and approximately 30% of breast cancer survivors continue to experience moderate to severe fatigue persisting as long at 10 years after completion of treatment. CTRF is multifactorial, but considerable evidence supports the model that inflammatory cytokines play a role. Multiple studies have found a correlation between fatigue and serum levels of IL-1RA and IL-6, two proinflammatory cytokines that are usually expressed together with TNF, and of neopterin, which is produced by macrophages in response to interferon gamma stimulation. Another study found that fatigued survivors had elevated numbers of T lymphocytes, suggesting chronic T cell activation as a driving force for the chronic inflammatory cytokines and fatigue.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2013
- Accession Number
- ADA599299
Entities
People
- Lisa Wood
Organizations
- Oregon Health & Science University